Egg Donation:
Evaluation of the Recipient Uterus
for Implantation
Endometrial Biopsy and Saline Infusion
Sonogram
In order to assess the uterus for implantation an endometrial biopsy
may be performed on a mock cycle.
Egg Donation: Mock Cycle/Biopsy for Recipient
Purpose: Assure normal uterine development for Embryo
implantation
Cycle #1.
_____ Menses start, begin BCPs on _____, Stop BCP on _____.
_____ Begin Lupron SQ, 10 IU daily until _____ (CD15 of next cycle)
Cycle #2.
_____CD1 Estrace 2 mg
_____CD2 “
_____CD3 “
_____CD4 “
_____CD5 “
_____CD6 Estrace 4 mg
_____CD7 “
_____CD8 “
_____CD9 “
_____CD10 Estrace 6 mg
_____CD11 “
_____CD12 “
_____CD13 “
_____CD14 “
_____CD15 “ , Last day Lupron, Ultrasound to check lining, if OK,
begin progesterone in oil, 2 cc’s /day IM.
_____CD16 “ , progesterone 2 cc’s IM
_____CD17 “ “
_____CD18 “ “ ,ENDOMETRIAL BIOPSY
Endometrial Biopsy
Background
The uterine lining, or endometrium, undergoes a specific sequence of
changes after ovulation during the luteal phase of the menstrual cycle in
order to develop a receptive environment for the developing embryo.
Estrogen followed by progesterone secretion by the ovaries is crucial for
the proper development of the lining. Abnormalities of uterine lining
development, or luteal phase defects, may be documented with an
endometrial biopsy. The may be associated with abnormal implantation.
Patient Protocol
1. Call the office with the onset of menses.
2. Call the office to schedule the biopsy 18 days later.
What to Expect
The biopsy is somewhat like a pap smear. After introducing a speculum
into the vagina, the cervix will be wiped with betadine to cleanse it. A
small catheter is then introduced into the cervix and the biopsy is
performed. It takes a few seconds. If you would like, you may take some
Anaprox or Dr. Donahue can give you a local anesthetic.
Most patients tolerate the procedure well and feel it is similar to the
HSG.
Additionally, we may do a saline infusion sonogram (SIS) to
see if there are any defects in the uterus that may affect implantation. A
trial embryo transfer is done at this time.
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